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Get an overview of our key publications.

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Our mission

To determine what drives the susceptibility to develop a disease

Patients with a similar genetic background may develop a heart disease very differently. Symptoms may range from mild to severe or even fatal. We aim to determine which factors drive these phenotypic differences  by generating patient-derived induced pluripotent stem cells, which we use to make patient-specific cardiac tissues.

Key publications

Visit the publications page for a complete overview.

Aberrant lipid metabolism in PPCM

Human iPSC-Derived Cardiomyocytes of Peripartum Patients With Cardiomyopathy Reveal Aberrant Regulation of Lipid Metabolism

OPLAH is a protective gene in heart failure

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH in heart disease


Dynamic loading of engineered cardiac tissues

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

Endotypes in heart failure

Novel endotypes in heart failure: effects on guideline-directed medical therapy


Novel function of KLHL24 in the heart

Gain-of-function mutation in ubiquitin-ligase KLHL24 causes desmin degradation and dilatation in hiPSC-derived engineered heart tissues

ASOs to treat PLN cardiomyopathy

Phospholamban Antisense Oligonucleotides Improve Cardiac Function in Murine Cardiomyopathy

EurObservational PPCM registry

Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry

Our Team

Peter van der Meer

Principal investigator

Nils Bömer

Postdoc

Niels Grote Beverborg

Postdoc

Martijn Hoes

Postdoc

Mathilde Vermeer

PhD student

Annet Linders

PhD student

Karla Arevalo Gomez

PhD student

Antonio Esquivel Gaytan

PhD student

Frits Deiman

PhD student

Sebatiaan Klaassen

MD/PhD student

Joost Beusekamp

MD/PhD student

Haye van der Wal

MD/PhD student

Ali Al Mubarak

MD/PhD student

Jumo Zhu

PhD student

Alwin Tubben

MD/PhD student